院训

曾乐勇 教授 博士生导师

一、个人简介

曾乐勇,男,1981年出生,九三学社社员,理学博士,教授,博士生导师,河北大学坤舆优秀学者,河北省杰出青年科学基金获得者。2005年于河北大学获物理学学士学位,2010年于中科院长春光机所获凝聚态物理博士学位,2010-2012年于中科院宁波材料所从事博士后研究,2012-2016年于中科院宁波材料所工作,历任助理研究员、副研究员,2016年-至今在河北大学化学与环境科学学院工作,目前是教授、博士生导师。主要从事纳米探针制备及其疾病诊疗应用研究,迄今已在Biomaterials等期刊发表学术论文50余篇,申请中国发明专利19项(已获授权13项)。主持国家自然科学基金(4项)、河北省杰出青年科学基金、河北省重点基础研究项目、河北省教育厅青年拔尖人才项目等10余项课题。特邀担任Adv. Funct. Mater., ACS Nano,Small, Nanoscale, ACS Appl. Mater. Interf., J. Mater. Chem.B等10余种国际主流期刊审稿人,是中国化学会、中国生物物理学会、中国生物材料学会和中美纳米医学与纳米生物技术学会会员,是中国医药生物技术协会纳米生物技术分会委员和中国抗癌协会纳米肿瘤学专业委员会青年委员。

联系方式:E-mail: zengly@hbu.cn手机号:17332186862(微信同号)

      热忱欢迎优秀的本科生和研究生加入课题组学习和发展!

二、主讲课程及研究方向

1.主讲课程:无机材料与制备化学、材料结构与表征、无机合成与表征实验 

2.研究方向:生物无机材料与纳米医学、化学生物学 

三、代表性论文

14. Zhibin Yin#, Qian Ji#, Di Wu, Ziwei Li, Minfei Fan, Hongxin Zhang, Xiaolong Zhao, Aiguo Wu*, Liang Cheng*, Leyong Zeng*. H2O2-Responsive Gold Nanoclusters @ Mesoporous Silica @ Manganese Dioxide Nanozyme for “Off/On” Modulation and Enhancement of Magnetic Resonance Imaging and Photodynamic Therapy. ACS Appl. Mater. Interfaces, 202113, 14928-14937.

13. Sijia Sun, Lining Zhao, Di Wu*, Hongxin Zhang, Haichen Lian, Xiaolong Zhao, Aiguo Wu, Leyong Zeng*. Manganese-doped carbon dots with redshifted orange emission for enhanced fluorescence and magnetic resonance imaging. ACS Appl. Bio Mater., 20214, 1969-1975.

12. Yang Gao#, Zhibin Yin#, Qian Ji*, Jiabing Jiang, Zhengzheng Tao, Xiaolong Zhao, Sijia Sun, Aiguo Wu*, Leyong Zeng*. Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy. J. Mater. Chem. B, 2021, 9, 314-321.

11Ziwei Li, Fan Yang, Di Wu*, Yanhong Liu, Yang Gao, Haichen Lian, Hongxin Zhang, Zhibin Yin, Aiguo Wu*, Leyong Zeng*. Ce6-conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer. Nanoscale, 2020, 12, 22173-22184.

10Yanhong Liu, Ziwei Li, Zhibin Yin, Hongxin Zhang, Yang Gao, Guoyan Huo*, Aiguo Wu*, Leyong Zeng*. Amplified photoacoustic signal and enhanced photothermal conversion of polydopamine coated gold nanobipyramids for photo-theranostics and synergistic chemotherapy. ACS Appl. Mater. Interfaces, 2020, 12, 14866-14875.

9. Yang Gao, Luyun Zhang, Yanhong Liu, Sijia Sun, Zhibin Yin, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*, Leyong Zeng*. Ce6/Mn2+-chelated polydopamine@Black-TiO2 nanoprobes for enhanced synergistic phototherapy and magnetic resonance imaging in 4T1 breast cancer. Nanoscale, 2020, 12, 1801-1810.

8. Luyun Zhang#, Yang Gao#, Sijia Sun, Zihou Li, Aiguo Wu*, Leyong Zeng*. pH-responsive metal-organic framework encapsulated gold nanoclusters with modulated release to enhance photodynamic therapy/chemotherapy in breast cancer. J. Mater. Chem. B, 2020, 8, 1739-1747.

7. Yang Gao, Sijia Sun, Zhibin Yin, Yanhong Liu, Aiguo Wu, Leyong Zeng*. TiO2 nanoparticles: Applications in nanobiotechnology and nanomedicine. Chapter 5: Cancer theranostics of white TiO2 nanomaterials. Wiley-VCH, 2020, 153-183.(英文专著章节)

6. Luyun Zhang#, Chuang Liu#, Yang Gao, Zihou Li, Jie Xing, Wenzhi Ren, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*, Leyong Zeng*. ZD2-engineered gold nanostar@metal-organic framework nanoprobes for T1-weighted magnetic resonance imaging and photothermal therapy specifically toward triple-negative breast cancer. Adv. Healthcare Mater., 2018, 7, 1801144.

5. Jie Feng, Limin Chen, Yuanzhi Xia, Jie Xing, Zihou Li, Qiuping Qian, Yan Wang, Aiguo Wu, Leyong Zeng*, Yunlong Zhou*. Bioconjugation of gold nanobipyramids for simultaneous SERS detection and targeted photothermal therapy in breast cancer. ACS Biomater. Sci. Eng., 2017, 3, 608-618.

4. Leyong Zeng, Yuanwei Pan, Ruifen Zou, Jinchao Zhang, Ying Tian, Zhaogang Teng, Shouju Wang, Wenzhi Ren, Xueshan Xiao, Jichao Zhang, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*. 808 nm-excited upconversion nanoprobes with low heating effect for targeted dual-modality imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer. Biomaterials, 2016, 103, 116-127.

3. Yuanwei Pan#, Ling’e Zhang#, Leyong Zeng*, Wenzhi Ren, Xueshan Xiao, Jichao Zhang, Lili Zhang, Aiguo Li, Guangming Lu*, Aiguo Wu*. Gd-based upconversion nanocarriers with yolk-shell structure for dual-modal imaging and enhanced chemotherapy to overcome multidrug resistance in breast cancer. Nanoscale, 2016, 8, 878-888.

2. Leyong Zeng, Yuanwei Pan, Ying Tian, Xin Wang, Wenzhi Ren, Shouju Wang, Guangming Lu*, Aiguo Wu*. Doxorubicin-loaded NaYF4: Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers. Biomaterials, 2015, 57, 93-106.

1. Ling’e Zhang, Leyong Zeng*, Yuanwei Pan, Song Luo, Wenzhi Ren, An Gong, Xuehua Ma, Hongze Liang, Guangming Lu*, Aiguo Wu*. Inorganic photosensitizer coupled Gd-based upconversion luminescent nanocomposites for in vivo magnetic resonance imaging and near-infrared-responsive photodynamic therapy in cancers. Biomaterials, 2015, 44, 82-90.

四、科研项目

1. 国家自然科学基金,项目批准号:517720742018.01-2021.1260万元,在研,主持人。

2. 国家自然科学基金,项目批准号:U17321272018.01-2020.1256万元,在研,主持人。

3.    河北省杰出青年科学基金,项目批准号:C20202010252020.09-2023.1250万元,在研,主持人。

4. 国家自然科学基金,项目批准号:U13321172014.01-2016.1270万元,已结题,主持人。

5. 河北省应用基础研究计划重点基础研究项目,项目批准号:17961302D2017.01-2019.1220万元,已结题,主持人。

6. 河北省教育厅青年拔尖人才项目,项目批准号:BJ20170022017.01-2019.128万元,在研,主持人。

7. 国家自然科学基金,项目批准号:511022512012.01-2014.1225万元,已结题,主持人。

五、荣誉称号

1.  2010年,中科院院长优秀奖。

2. 2015年,宁波市领军拔尖人才(第二层次)。

3.  2015年,中科院青年创新促进会。

4. 2016年,宁波市科学技术一等奖(排名第二)。

5. 2017年,河北省教育厅青年拔尖人才。

6. 2018年,河北大学坤舆优秀学者。

7. 2020年,河北省杰青。





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