院训

张金超

一、个人简介
 
      张金超, 浙江大学博士 (1998-2001),北京大学博士后(2001-2003),香港城市大学高级访问学者(2003-2006),现为教授,博士研究生导师,河北省自然科学基金杰出青年基金获得者、河北省青年科技奖获得者、河北省新世纪“三三三人才工程”第一层次人选、河北省高校百名优秀创新人才、河北省政府特殊津贴专家;现任河北大学化学与环境科学学院院长、药物化学与分子诊断教育部重点实验室常务副主任以及河北省化学生物学重点实验室主任。迄今为止,发表SCI收录论文150余篇;获授权中国发明专利 20余项,先后主持了国家“重大新药创制”科技重大专项、国家自然科学基金、教育部科学技术研究重点项目、河北省自然科学基金杰出青年基金、河北省自然科学基金重点项目、河北省应用基础研究计划重点基础研究项目等20余项课题。
 联系方式:E-mail: jczhang6970@163.com
 
二、主讲课程及研究方向
1.主讲课程:有机化学,生物无机化学,化学生物学
2.研究方向:纳米医学与分子诊疗。
 
三、代表性论文
 
1.Anil Kumar, Shuaidong Huo, Xu Zhang, Juan Liu, Aaron Tan, Shengliang Li, Shubin Jin, Xiangdong Xue, YuanYuan Zhao, Tianjiao Ji, Lu Han, Hong Liu, Xiaoning Zhang*Jinchao Zhang*, Guozhang Zou, Tianyou Wang*, Suoqin Tang, and Xing-Jie Liang*Neuropilin-1-targeted gold nanoparticles enhance therapeutic efficacy of platinum(IV) drug for prostate cancer treatmentACSNano2014, 8(5),  4205-4220.
2.Xiaohong Hao, Xixue Hu, Cuimiao Zhang, Shizhu Chen, Zhenhua Li, Xinjian Yang, Huifang Liu, Guang Jia,* Dandan Liu, Kun Ge, Xing-Jie Liang,* and Jinchao Zhang*Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite.  ACSNano2015, 9(10), 9614-9625.
3. Kun Ge, Cuimiao Zhang, Guang Jia,* Huihui Ren, Jianyuan Wang, Aaron Tan, Xing-Jie Liang,* Aimin Zang and Jinchao Zhang*. Defect-related luminescent mesoporous silica nanoparticles employed for novel detectable nanocarrier. ACS Appl. Mater Interfaces2015, 7, 10905-10914.
4.Yaqiong Dong, Jun Yang, Hongmei Liu, Tianyou Wang, Suoqin Tang, Jinchao Zhang* and Xin Zhang*Site-specific drug-releasing polypeptide nanocarriers based on dual-pH response for enhanced therapeutic efficacy against drug-resistant tumors. Theranostics, 2015, 5(8), 890-904.
5.Ran Zhang, Yan Li, Bingbing Hu, Zhiguo Lu, Jinchao Zhang*, Xin Zhang*. Traceable nanoparticle delivery of small interfering RNA and retinoic acid with temporally release ability to control neural stem cell differentiation for Alzheimer’s disease therapyAdv Mater2016, 28, 6345-6352.
6. Kun Ge, Cuimiao Zhang, Wentong Sun, Huifang Liu, Yi Jin, Zhenhua Li, Xing-Jie Liang, Guang Jia,* Jinchao Zhang*.Up-conversion Y2O3:Yb3+, Er3+ hollow spherical drug carrier with improved degradability for cancer treatment. ACS Appl Mater Interfaces, 2016, 8: 25078−25086.
7.Weipei Feng, Chunyue Gao, Wei Liu, Huihui Ren, Chao Wang, Kun Ge, Shenghui Li, Guoqiang Zhou, Hongyan Li, Shuxiang Wang,* Guang Jia, Zhenhua Li,  Jinchao Zhang*. A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential controlChem Commun, 2016, 52, 9434-9437.
8. Chao Wang, Dandan Liu, Cuimiao Zhang, Jiadong Sun, Weipei Feng, Xing-Jie Liang,Shuxiang Wang,* Jinchao Zhang*.Defect-related luminescent hydroxyapatite-enhanced osteogenic differentiation of bone mesenchymal stem cells via an ATP-induced cAMP/PKA pathwayACS Appl Mater Interfaces2016, 8, 11262−11271.
9.Shizhu Chen, Keni Yang, Ruslan G. Tuguntaev, Anbu Mozhi, Jinchao Zhang*, Paul C. Wang, Xing-Jie Liang*Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistanceNanomedicine: NBM, 2016, 12, 269–286.
10.Shizhu Chen, Xiaohong Hao, Xingjie Liang, Qun Zhang, Cuimiao Zhang, Guoqiang Zhou,Shigang Shen, Guang Jia, and Jinchao Zhang. Inorganic nanomaterials as carriers for drug deliveryJ Biomed Nanotechnol2016, 12, 1-27.
11. Hongliang Li, Wen Peng, Weipei Feng, Yuechai Wang, G. Chen, Shuxiang Wang*, Shenghui Li, Hongyan Li, Kerang Wang, Jinchao Zhang*. A novel dual-emission fluorescent probe for the simultaneous detection of H2S and GSHChem. Commun., 2016, 52, 4628–4631.
12. Fei Duan, Xiaochen Feng, Xinjian Yang, Wentong Sun, Yi Jin, Huifang Liu, Kun Ge, Zhenhua Li*, Jinchao Zhang*A simple and powerful co-delivery system based on pH-responsive metal-organic frameworks for enhanced cancer immunotherapyBiomaterials2017, 122, 23-33.
13. Huifang Liu, Yi Jin, Kun Ge, Guang Jia, Zhenhua Li, Xinjian Yang, Shizhu Chen, Min Ge, Wentong Sun, Dandan Liu*, and Jinchao Zhang*. Europium-doped Gd2O3 nanotubes increase bone mineral density in vivo and promote mineralization in vitroACS Appl. Mater. Interfaces2017, 9, 5784-5792.
14. Yi Jin, Zhenhua Li, Huifang Liu, Shizhu Chen, Feng Wang, Ling Wang, Nan Li, Kun Ge, Xinjian Yang*, Xing-Jie Liang*, Jinchao Zhang*Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapyNPG Asia Materials2017, 9, e365.
15.Fei Duan, Xiaochen Feng, Yan Jin, Dawei Liu, Xinjian Yang, Guoqiang Zhou, Dandan Liu, Zhenhua Li*, Xing-Jie Liang*, Jinchao Zhang*. Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of MRSA. Biomaterials2017, 144, 155-165.
16.Shutao Gao, Pengli Zheng, Zhenhua Li*, Xiaochen Feng, Weixiao Yan, Shizhu Chen, Weisheng Guo, Dandan Liu, Xinjian Yang, Shuxiang Wang, Xing-Jie Liang*, Jinchao Zhang*Biomimetic O2-Evolving metal-organic framework nanoplatform for highly efficient photodynamic therapy against hypoxic tumorBiomaterials2018, 178, 83-94.
17.Hongjuan Li#, Weixiao Yan#, Xiaomin Su, Haotong Peng, Xinjian Yang, Zhenhua Li, Jinchao Zhang*, Dandan Liu*. Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapyBiomaterials2019, 200, 1-14.
18.Chunyue Gao, Yi Jin*, Guang Jia, Xiaoming Suo, Huifang Liu, Dandan Liu, Xingjian Yang, Kun Ge, Xing-jie Liang, Shuxiang Wang*Jinchao Zhang*Y2O3 nanoparticles caused bone tissue damage by breaking the intracellular phosphate balance in bone marrow stromal cells. ACSNano2019, 13, 313-323.
19.Wentong Sun, Kun Ge*, Yan Jin, Yu Han, Haisong Zhang, Guoqiang Zhou, Xinjian Yang, Dandan Liu, Huifang Liu, Xing-Jie Liang, Jinchao Zhang*Bone-Targeted Nanoplatform Combining Zoledronate and Photothermal Therapy ToTreat Breast Cancer Bone Metastasis. ACS Nano2019, 13, 7556–7567.
20.Shutao Gao, Yan Jin, Kun Ge, Zhenhua Li,* Huifang Liu, Xinyue Dai, Yinghua Zhang,Shizhu Chen, Xingjie Liang,* and Jinchao Zhang*Self-supply of O2 and H2O2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapyAdv. Sci2019, 1902137.
21.Xiaowei Ma, # Jiadong Sun, # Lin Zhong, Yufei Wang, Qianqian Huang, Xiaoli Liu, Shubin Jin,* Jinchao Zhang,* and Xing-Jie Liang*. Evaluation of Turning-Sized Gold Nanoparticles on Cellular Adhesion by Golgi Disruption in Vitro and in VivoNano Lett. 2019, 19, 8476-8487
 四、科研项目
1.人工稀土纳米材料对骨髓基质细胞成骨分化和成脂分化的调控及分子机制(项目批准号:21271059), 国家自然科学基金项目( 2013-2016年, 主持人)
2.基于pH响应、可将接介孔二氧化硅/磷灰石复合纳米颗粒的制备及其在抗肿瘤方面的应用(项目批准号:31470961), 国家自然科学基金项目(2014-2017年, 主持人)
3.基于多级MOF的纳米级联催化体系的构建及其用于肿瘤治疗的研究(批准号:31971304), 国家自然科学基金面上项目(2020-2023年,主持人)
4.靶向肿瘤干细胞的多功能磁性二氧化硅纳米载药体系的构建及其抗肿瘤作用研究(项目批准号:B2017201226),河北省自然科学基金重点项目(2017-2019年, 主持人)
五、获奖
1. 骨质疏松症防治的基础与应用研究,2017年河北省科技进步三等奖(第一名)
2.新型贵金属类抗肿瘤配合物的设计、合成及机制研究; 2014年河北省自然科学二等奖(第一名)
3. 新型铂类抗肿瘤药物的设计、合成及其作用机制,2019年河北省自然科学一等奖(第一名)

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