院训

王书香

一、个人简介

王书香, 河北大学博士 (2003-2005),教授,硕士研究生导师。迄今为止,发表SCI收录论文60余篇;获授权中国发明专利 6项,主持或参与科研课题多项。

联系方式:E-mail: wsx@hbu.edu.cn

二、主讲课程及研究方向

1.主讲课程:有机化学

2.研究方向:有机合成、抗肿瘤药物合成、肿瘤的诊断与治疗、生物小分子探针

三、代表性论文

1. Chunyue Gao, Yi Jin*, Guang Jia, Xiaomin Suo, Huifang Liu, Dandan Liu, Xinjian Yang, Kun Ge, Xing-Jie Liang, Shuxiang Wang*, Jinchao Zhang*. Y2O3 nanoparticles caused bone tissue damage by breaking the intracellular phosphate balance in bone marrow stromal cells. ACS Nano, 2019, 13 (1), 313-323.

2. Xiaoran Peng, Jiaxin Gao, Yumeng Yuan, Haitong Liu, Weiyan Lei, Shenghui Li, Jinchao Zhang, Shuxiang Wang, Hypoxia-Activated and Indomethacin-Mediated Theranostic Prodrug Releasing Drug On-Demand for Tumor Imaging and Therapy, Bioconjugate Chem. 2019, 30, 2828−2843

3. Hongliang Li, Weiyan Lei, Jianong Wu, Shenghui Li, Guoqiang Zhou,* Dandan Liu, Xinjian Yang, Shuxiang Wang,* Zhenhua Li and Jinchao Zhang, An upconverting nanotheranostic agent activated by hypoxia combined with NIR irradiation for selective hypoxia imaging and tumour therapy, J. Mater. Chem. B, 2018, 6, 2747-2757.

4. Wei Liu, Haitong Liu, Xiaoran Peng, Guoqiang Zhou,* Dandan Liu, Shenghui Li, Jinchao Zhang,* and Shuxiang Wang,* Hypoxia-Activated Anticancer Prodrug for Bioimaging, Tracking Drug Release, and Anticancer Application. Bioconjugate Chem. 2018, 29, 3332−3343.

5. Chao Wang, Dandan Liu, Cuimiao Zhang, Jiadong Sun, Weipei Feng, Xing-Jie Liang, Shuxiang Wang,* Jinchao Zhang*. Defect-Related Luminescent Hydroxyapatite-Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells Via an ATP-Induced cAMP/PKA Pathway. ACS Appl. Mater. Interfaces, 2016, 8, 11262-11271.

6. Hongliang Li, Wen Peng, Weipei Feng, Yuechai Wang, Guofeng Chen, Shuxiang Wang*, Shenghui Li, Hongyan Li, Kerang Wang, Jinchao Zhang*. A novel dual-emission fluorescent probe for the simultaneous detection of H2S and GSH. Chem. Commun., 2016, 52, 4628-4631.

7. Weipei Feng, Chunyue Gao, Wei Liu, Huihui Ren, Chao Wang, Kun Ge, Shenghui Li, Guoqiang Zhou, Hongyan Li, Shuxiang Wang,* Guang Jia, Zhenhua Li, Jinchao Zhang*. A novel anticancer theranostic pro-prodrug based on hypoxia and photo sequential control. Chem. Commun., 2016, 52, 9434-9437.

8. Weipei Feng, Yuechai Wang, Shizhu Chen, Chao Wang, Shuxiang Wang*, Shenghui Li, Hongyan Li, Guoqiang Zhou, Jinchao Zhang*. 4-Nitroimidazole-3-hydroxyflavone conjugate as a fluorescent probe for hypoxic cells. Dyes and Pigments, 2016, 131, 145-153.

四、科研项目

1. (1,2-b)喹喔啉-5,10-二氧-11-酮肟醚类乏氧激活性抗肿瘤前药的设计、合成与抗肿瘤机制研15962602D)河北省应用基础研究计划重点基础研究项目(2015-2017年,主持

2. 乏氧激活性光热剂/热休克蛋白90抑制剂缀合物的合成与抗三阴性乳腺癌研究(B2019201444河北省自然科学基金(2019-2021主持)

五、获奖(本人是第一完成人或参与人,河北大学为第一位完成单位获得的政府奖励)

1. 超声辐射下邻二醇的合成及机理研究,2007年河北省自然科学奖(三等,第二名)

2. 新型贵金属类抗肿瘤配合物的设计、合成及机制研究,2014年河北省自然科学奖(二等,第三名)

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