王克让
一、个人简介
王克让, 南开大学博士 (2006-2009)，导师：刘育 教授。现为教授，博士研究生导师，河北省自然科学基金杰出青年基金获得者、河北省“三三三人才工程”第三层次人选。迄今为止，在Nat. Commun.、ACS Nano、Adv. Funct. Mater.、J. Med. Chem.、Mater. Horiz.和Chem. Commun.等上发表研究论文60多篇；获授权中国发明专利10项，先后主持了国家自然科学基金、河北省自然科学基金杰出青年基金、河北省创新能力提升计划项目和河北省自然科学基金等10多项课题，撰写《圆二色谱的原理及其应用》专著一部（科学出版社）。
联系方式：E-mail: kerangwang@163.com.
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二、主讲课程及研究方向
1.主讲课程：有机化学
2.研究方向：超分子化学、糖化学
三、代表性论文
39. Yan-Qin Geng#, Li-Na Qiu#, Yuan-Qiu Cheng#, Juan-Juan Li, Yi-Lin Ma, Cheng-Cheng Zhao, Ying Cai, Xue-Bin Zhang, Jieli Chen, Yu-Chen Pan, Ke-Rang Wang*, Xiu-Hua Yao*, Dong-Sheng Guo*, Jia-Ling Wu*. Alleviating recombinant tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke via targeted delivery of a ferroptosis inhibitor. Adv. Sci., 2024, DOI: 10.1002/advs.202309517.
38. Guang-Yuan Wang, Dong-Xiao Yan, Rui-Xue Rong, Bing-Ye Shi, Gao-Juan Lin, Fangqian Yin, Wen-Tong Wei, Xiao-Liu Li*, Ke-Rang Wang*. Amphiphilic α-peptoid-deoxynojirimycin conjugates-based multivalent glycosidase inhibitor for hypoglycemic effect and fluorescence imaging. J. Med. Chem., 2024, 67, 5945-5956. Supplementary Cover.
37. Ying-Ying Zhao, Jie Kang, Hai-Yan Liu, Dong-Mei Xi, Ke-Rang Wang*. Dynamic fluorescence imaging and controllable capture/release of guests based on thermo-responsive perylene-cyclodextrin conjugates. Dyes Pigments, 2024, 223, 111937.
36. Yan Yang, Dong-Xiao Yan, Rui-Xue Rong*, Bing-Ye Shi, Man Zhang, Jing Liu, Jie Xin, Tao Xu, Wen-Jie Ma, Xiao-Liu Li*, Ke-Rang Wang*. Nucleolus imaging based on Naphthalimide derivatives. Bioorg. Chem., 2024, 142, 106969.
35. Shihui Li#, Juan-Juan Li#, Ying-Ying Zhao, Meng-Meng Chen, Shan-Shan Su, Shun-Yu Yao, Ze-Han Wang, Xin-Yue Hu, Wen-Chao Geng, Wei Wang*, Ke-Rang Wang*, Dong-Sheng Guo*. Supramolecular integration of multifunctional nanomaterial by mannose-decorated azocalixarene with Ginsenoside Rb1 for synergistic therapy of rheumatoid arthritis. ACS Nano, 2023, 17, 25468-25482.
34. Bing Hu, Juan-Juan Li, Yan-Bin Ren, Tian-Xing Zhang, Li-Bin Chen, Xiao-Liu Li, Dong-Sheng Guo*, Ke-Rang Wang*. Calixarene-based cryoprotectants for ice recrystallization inhibition and cell cryopreservation. J. Mater. Chem. B, 2023, 11, 11222-11227.
33. Fangqian Yin, Juan-Juan Li, Bingsen Shi, Kai Zhang, Xiao-Liu Li, Ke-Rang Wang*, Dong-Sheng Guo*. Carbohydrate-macrocycle conjugates for biomedical applications. Mater. Chem. Front., 2023, 7, 5263-5287.
32. Juan-Juan Li#, Rui-Xue Rong#, Yan Yang, Zong-Ying Hu, Bing Hu, Ying-Ying Zhao, Hua-Bin Li, Xin-Yue Hu*, Ke-Rang Wang*, Dong-Sheng Guo*. Triple targeting host-guest drug delivery system based on lactose-modified azocalix[4]arene for tumor ablation. Mater. Horiz., 2023, 10, 1689-1696.
31. Guang-Yuan Wang, Wen-Tong Wei, Rui-Xue Rong, Shan-Shan Su, Dong-Xiao Yan, Fang-Qian Yin, Xiao-Liu Li*, Ke-Rang Wang*. Fluorescence sensing and glycosidase inhibition effect of multivalent glycosidase inhibitors based on naphthalimide-deoxynojirimycin conjugates. Bioorg. Chem., 2023, 132, 106373.
30. Juan-Juan Li#, Yuqing Hu#, Bing Hu, Wenbo Wang, Haiqi Xu, Xin-Yue Hu, Fei Ding, Hua-Bin Li, Ke-Rang Wang*, Xinge Zhang*, Dong-Sheng Guo*. Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer. Nat. Commun., 2022, 13, 6279.
29. Bing Hu, Guo-Kai Li, Guo-Min Ai, Man Zhang, Shan-Shan Su, Xu He, Xiao-Liu Li,* Ke-Rang Wang*. Macrocycle molecule-based cryoprotectants for ice recrystallization inhibition and cell cryopreservation. J. Mater. Chem. B, 2022, 10, 6922-6927.
28. Jian-Xing Yang, Juan-Juan Li, Fang-Qian Yin, Guang-Yuan Wang, Wen-Tong Wei, Xiao-Liu Li,* Ke-Rang Wang*. Multivalent glucosidase inhibitors based on perylene bisimide and iminosugar conjugates. Eur. J. Med. Chem., 2022, 241, 114621.
27. Yu-Ming Qi, Jie Xin, Jin-Mei Li, Xiao-Liu Li, Ke-Rang Wang*. Biogenic amine sensing and cancer detection in human urine based on a light-activated photocatalytic and pH-controlled probe. Sens. Actuators B Chem., 2022, 367, 132037.
26. Ya-Li Luo, Hui-Yan Zhang, Guo-Kai Li, Ying-Ying Zhao, Yan Yang, Rui-Xue Rong, Xiao-Liu Li*, Ke-Rang Wang*. Synthesis, renal clearance, and photothermal therapy based on the self-assembly of a nanomedicine consisting of quaterrylene bisimide and glycocluster conjugates. ACS Macro Lett., 2022, 11, 615-621.
25. Xu He#, Bing Hu#, Yan Yang, Hong-Yu Zhu, Rui-Xue Rong, Xiao-Liu Li*, Ke-Rang Wang*. Synthesis, self-aggregate and cryopreservation effects of perylene bisimide-glycopeptide conjugates. Chem. Commun., 2021, 57, 12000-12003.
24. 李仁风, 杨建星, 张慧妍, 王克让*, 李小六*. 基于苝单酰亚胺-野尻霉素的自组装多效价糖苷酶抑制剂研究, 中国科学: 化学, 2021, 51, 1276-1282. (河北大学百年校庆专刊)
23. Shan-Shan Wang,# Shao-Ying Du,# Xu He, Yu-Ming Qi, Xiao-Liu, Li,* Rui-Xue Rong,* Zhi-Ran Cao,* Ke-Rang Wang*. Nucleus-targeting imaging and enhanced cytotoxicity based on naphthalimide derivatives. Bioorg. Chem., 2021, 115, 105188.
22. Jin-Mei Li, Ke-Rang Wang*. Universal colorful staining of cancer tissues and normal tissues for histological diagnosis. Analyst, 2021, 146, 4446-4449.
21. Ren-Feng Li#, Jian-Xing Yang#, Jing Liu, Guo-Min Ai, Hui-Yan, Zhang, Li-Yue Xu, Si-Bing Chen, Hong-Xin Zhang, Xiao-Liu Li*, Zhi-Ran Cao*, Ke-Rang Wang*. Positional isomeric effects on the optical properties, multivalent glycosidase inhibition effect and hypoglycemic effect of perylene bisimide-deoxynojirimycin conjugates. J. Med. Chem., 2021, 64, 5863-5873.
20. Jun-Fang Wang, Chun-Miao Zhao, Jian-Xing Yang, Xu He, Xiao-Liu Li, Jin-Mei Li*, Ke-Rang Wang*. Selective sensing of DNA and live/dead cells and histological imaging based on a perylene derivative. Chem. Commun., 2021, 57, 2776-2779.
19. Ya-Li Luo, Rui-Xue Rong, Jin-Mei Li, Xiao Chen, Shan-Shan Wang, Xiao-Liu Li*, Ke-Rang Wang*. Effective renal clearance and photothermal therapy of cyclodextrin modified quaterrylene derivative. ACS Appl. Bio Mater., 2020, 3, 3390-3400.
18. Xuan Liu, Ke-Rang Wang*, Rui-Xue Rong, Mao-Hua Liu, Qi Wang, Xiao-Liu Li*. Host-guest controlled assembly and recognition of perylene bisimide-based glycocluster with cyclodextrin. Dyes Pigments, 2020, 174, 108043.
17. Jiu-Kai Xiong, Ke-Rang Wang,* Kai-Xin Wang, Tian-Lei Han, Hong-Yu Zhu, Rui-Xue Rong, Zhi-Ran Cao, Xiao-Liu Li*. Fluorescent enhancement sensing of Cadmium (II) ion based on a perylene bisimide derivative. Sens. Actuators B Chem., 2019, 297, 126802.
16. Chun-Miao Zhao, Ke-Rang Wang*, Chong Wang, Xu He, Xiao-Liu Li*. Cooling-induced NIR emission enhancement and targeting fluorescence imaging of bi-perylene monoimide and glycodendrimer conjugates. ACS Macro Lett., 2019, 8, 381-386.
15. Juan-Juan Li, Ke-Rang Wang*, Ren-Feng Li, Jian-Xing Yang, Min Li, Hong-Xin Zhang, Zhi-Ran Cao, Xiao-Liu Li*. Synthesis, self-assembly behaviours and multivalent glycosidase inhibition effect of deoxynojirimycin modified perylene bisimide derivatives. J. Mater. Chem. B, 2019, 7, 1270-1275.
14. Min Li, Ke-Rang Wang*, Jian-Xing Yang, Ya-Tong Peng, Yi-Xuan Liu, Hong-Xin Zhang, Xiao-Liu Li*. Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors. J. Mater. Chem. B, 2019, 7, 1379-1383.
13. Xiao Chen, Ya-Nan Wang, Rui-Xue Rong, Chun-Miao Zhao, Xiao-Liu Li*, Ke-Rang Wang*. Synthesis, thermos-responsive behavior of cyclodextrin modified bi-perylene monoimide derivative. Dyes Pigments, 2019, 160, 779-786.
12. Qian Sun, Hong-Yu Zhu, Jun-Fang Wang, Xiao Chen, Ke-Rang Wang*, Xiao-Liu Li. Supramolecular Nanofiber of Pyrene-lactose Conjugates and its Two-photon Fluorescence Imaging. Bioorg. Chem., 2018, 79, 126-130.
11. Qi Xu, Jia-Li Wang, Ya-Li Luo, Juan-Juan Li, Ke-Rang Wang*, Xiao-Liu Li*. Host-guest interactions and controllable capture and release of proteins based on cationic perylene bisimides. Chem. Commun., 2017, 53, 2241-2244.
10. Guo-Jing Cao, Rui-Xue Rong, Ya-Nan Wang, Qi Xu, Ke-Rang Wang*, Xiao-Liu Li*. Synthesis and photodynamic therapy of mono-mannose modified perylene bisimide bridged permethyl-β-CDs. Dyes Pigments, 2017, 136, 569-576.
9. Ke-Rang Wang*, Zi-Bo Yang, Xiao-Liu Li*. High excimer-state emission of perylene bisimides and its recognition of Latent fingerprints. Chem. Eur. J., 2015, 21, 5680-5684.
8. Ke-Rang Wang*, Dan Han, Guo-Jing Cao, Xiao-Liu Li*. Synthesis and predetermined supramolecular chirality of carbohydrates functionalized perylene bisimide derivatives. Chem. Asian J., 2015, 10, 1204-1214.
7. Ke-Rang Wang*, Hong-Wei An, Rui-Xue Rong, Zhi-Ran Cao, Xiao-Liu Li*. Synthesis of biocompatible glycodendrimer based on fluorescent perylene bisimides and its bioimaging. Macromol. Rapid Commun., 2014, 35, 727-734.
6. Ke-Rang Wang*, Hong-Wei An, Rui-Xue Rong, Zhi-Ran Cao, Xiao-Liu Li*. Fluorescence turn-on sensing of protein based on mannose functionalized perylene bisimides and its fluorescence imaging. Biosens. Bioelectron., 2014, 58, 27-32.
5. Ke-Rang Wang, Yue-Qing Wang, Hong-Wei An, Jin-Chao Zhang, Xiao-Liu Li*. A triazatruxene-based glycoclusters as a fluorescent sensor for Concanavalin A. Chem. Eur. J., 2013, 19, 2903–2909.
4. Ke-Rang Wang, Hong-Wei An, Ling Wu, Jin-Chao Zhang, Xiao-Liu Li*. Chiral self-assembly of lactose functionalized perylene bisimides as multivalent glycoclusters. Chem. Commun., 2012, 48, 5644–5646.
3. Ke-Rang Wang, Dong-Sheng Guo, Bang-Ping Jiang, Yu Liu*. Excitonic coupling interactions in the self-assembly of perylene-bridged bis (β-cyclodextrin)s and porphyrin. Chem. Commun., 2012, 48, 3644–3646.
2. Ke-Rang Wang, Dong-Sheng Guo, Bang-Ping Jiang, Zhan-Hu Sun, Yu Liu*. Molecular Aggregation Behavior of Perylene-Bridged Bis (β-cyclodextrin)s and its Electron Interactions upon Selective Binding with Aromatic Guests. J. Phys. Chem. B, 2010, 114, 101-106.
1. Yu Liu*, Ke-Rang Wang, Dong-Sheng Guo, Bang-Ping Jiang. Supramolecular Assembly of Perylene Bisimide with β-Cyclodextrin Grafts as Solid-State Fluorescent Sensor for Vapor Detection. Adv. Funct. Mater., 2009, 19, 2230-2235.
四、科研项目
1. 两亲糖基共组装体的构筑及糖尿病溃疡研究，河北省高等学校科学研究项目-基础研究重点培育专项：项目编号：JZX2024018，起止时间：2024/01-2026/12，主持.
2. 乏氧响应的主客体药物递送体系，国家自然科学基金-区域创新发展联合基金，项目编号：U20A20259，起止时间：2021/01-2024/12，参与.
3. 基于类肽-野尻霉素类多效价糖苷酶抑制剂的活性及降糖作用研究，河北省自然科学基金-生物医药联合基金重点项目，项目编号：B2020201092，起止时间：2021/01-2023/12，主持.
4. 类肽-野尻霉素类多效价降糖分子研究，河北大学多学科交叉项目，项目编号：DXK202004，起止时间：2021/01-2023/12，主持.
5. 自组装糖肽纳米组装体的抗冻功能研究，河北省创新能力提升计划项目（京津冀协同创新专项），项目编号：19241303D，起止时间：2019/01-2021/06，主持.
6. 苝酰亚胺-野尻毒素超分子多效价糖苷酶抑制剂的研究，河北省自然科学基金（杰出青年基金），项目编号: B2016201254，起止时间：2016/01-2018/12，主持.
7. 苝-环糊精-糖类超分子多效价糖基组装体的构筑、识别和靶向给药研究，国家自然科学基金（面上项目），项目编号: 21372059，起止时间：2014/01-2017/12，主持.
8. 苝-环糊精-糖类多效价糖基组装体的构筑和性质研究，河北省高等学校科学技术研究项目（优秀青年基金），项目编号: YQ2013006，起止时间：2013/01-2015/12，主持.
9. 多胺连接萘酰亚胺类和二氯乙酰胺类抗肿瘤化合物的合成及性质研究，河北省自然科学基金-石药基团医药联合研究基金，项目编号: B2012201041，起止时间：2012/01-2014/12，主持.
10. 苝-糖类衍生物超分子多效价组装体的构筑及与凝集素作用研究，国家自然科学基金项目（青年基金），项目编号: 21002020，起止时间：2011/01-2013/12，主持.
11. 苝-糖类衍生物超分子多效价组装体的构筑及与凝集素的识别研究，河北省自然科学基金（青年基金），项目编号: B2011201052，起止时间：2011/01-2013/12，主持.
12. 新型苝-糖类衍生物超分子组装体的构筑及与凝集素的传感研究，河北省高等学校科学技术研究项目（青年基金），项目编号: 2010106，起止时间：2011/01-2012/12，主持.
