卢晓慧

一、 个人简介

卢晓慧，女，2020年毕业于陕西师范大学化学化工学院，获得理学博士学位。迄今为止发表SCI收录论文10余篇，先后主持和参与国家自然科学基金项目各一项。

联系方式：luxh@hbu.edu.cn

二、 主要研究方向

基于微纳米材料的生物化学传感、生化分析与分子诊断

三、 科研项目

(1) 国家自然科学基金委员会, 青年科学基金项目（C类）, 数字式SERS成像技术同时分析多种microRNAs用于癌症早期诊断, 2023-01-01 至 2024-12-31, 主持；

(2) 国家自然科学基金委员会, 面上项目,基于单颗粒计数机制的外泌体RNA标志物绝对定量新方法研究, 2021-01-01 至 2024-12-31, 参与；

(3) 深圳市科技创新委员会，优秀科技创新人才培养项目：基于单颗粒表面链替换反应的数字式SERS成像技术检测外泌体microRNA，2022-04-01至2024-04-01，主持；

(4) 河北大学高层次人才科研启动项目，2025-2028年，主持。

四、 代表性论文

1. Xiaohui Lu^#, Chen Hu^#, Dailu Jia, Wenjiao Fan, Wei Ren*, Chenghui Liu*. Amplification-Free and Mix-and-Read Analysis of Multiplexed MicroRNAs on a Single Plasmonic Microbead, Nano Letters, 2021, 21(15): 6718-6724.

2. Xiaohui Lu, Chanyu Yao, Linlin Sun, Zheng Li*. Plasmon-enhanced biosensors for microRNA analysis and cancer diagnosis. Biosensors and Bioelectronics, 2022, 203, 114041.

3. Xiaohui Lu, Dongdong Zhang, Xiaofeng Chen, Chanyu Yao, Zheng Li*. Interfacial Profiling of MicroRNAs at Patterned Nanogaps for an Integrated Microfluidic-SERS Liquid Biopsy. Analytical Chemistry, 2023, 95(44): 16049–16053.

4. Xiaohui Lu, Wei Ren, Chen Hu, Chenghui Liu,* Zhengping Li*. Plasmon-enhanced surface-enhanced Raman scattering mapping concentrated on a single bead for ultrasensitive and multiplexed immunoassay. Analytical Chemistry, 2020, 92(18): 12387-12393.

5. Xiaohui Lu, Zheng Li*. Patterned microarrays or nanoscale assemblies for optical sensing of biomarkers. Trends in Analytical Chemistry. 2024, 179, 117873.

6. Chanyu Yao,^# Xueliang Liu,^# Xiaohui Lu,^#Lei Wang, Jia Jia, and Zheng Li*. Smartphone-based Fluorescent Profiling of Quaternary MicroRNAs in Urine for Rapid Diagnosis of Urological Cancers using a Multiplexed Isothermal Exponential Amplification Reaction. Analytical Chemistry, 2024, 96(1): 419-426.

7. Xiaohui Lu, Wenjiao Fan, Qinya Feng, Yan Qi, Chenghui Liu,* and Zhengping Li. A versatile dynamic light scattering strategy for the sensitive detection of plant microRNAs based on click-chemistry-amplified aggregation of gold nanoparticles. Chemistry-A European Journal, 2019, 25(7): 1701-1705.

8. Xiaohui Lu, Peipei Wang, Yucong Wang*, Chenghui Liu*, Zhengping Li. A versatile dual-emission fluorescent microhybrid enabling visual detection of glucose and other oxidases-based biocatalytic systems. Advanced Materials Technologies. 2016, 1(2): 1600024.

9. Xiaohui Lu, Yunjie Zhao, Jinjun Zhang, Xiaozhen Lu,Yucong Wang*, Chenghui Liu*. Copper ion-induced fluorescence band shift of CdTe quantum dots: a highly specific strategy for visual detection of Cu²⁺ with a portable UV lamp. Analyst, 2015, 140(23): 7859-7863.

10. Xiaohui Lu, Kenneth S. Suslick*, Zheng Li*. Nanoparticle Optical Sensor Arrays: Gas Sensing and Biomedical Diagnosis. Analysis & Sensing, 2022, 3(2):e202200050.

11. Yan Qi, Xiaohui Lu, Qinya Feng, Wenjiao Fan, Chenghui Liu* and Zhengping Li*. An Enzyme-Free MicroRNA Assay Based-on Fluorescence Counting of Click Chemical Ligation-Illuminated Magnetic Nanoparticles with Total Internal Reflection Fluorescence Microscopy. ACS Sensors, 2018, 3, 2667-2674.

12. Wenxia Yang, Xiaohui Lu, Yucong Wang*, Sujuan Sun, Chenghui Liu*, Zhengping Li. Portable and sensitive detection of protein kinase activity by using commercial personal glucose meter. Sensors and Actuators B: Chemical, 2015, 210, 508-512.

13. Yueying Sun, Xiaohui Lu, Fengxia Su, Limei Wang, Chenghui Liu, Xinrui Duan, Zhengping Li*. Real-time fluorescence ligase chain reaction for sensitive detection of single nucleotide polymorphism based on fluorescence resonance energy transfer. Biosensors and Bioelectronics. 2015, 74: 705-710.

14. Liping Zhu, Desheng Chen, Xiaohui Lu, Yan Qi, Pan He, Chenghui Liu* and Zhengping Li. An Ultrasensitive Flow Cytometric Immunoassay Based on BeadsurfaceInitiated Template-Free DNA Extension. Chemical Science, 2018, 9, 6605-6613.

15. Wenjiao Fan, Yan Qi, Xiaohui Lu, Wei Ren, Chenghui Liu* and Zhengping Li. An Emulsion-Free Digital Flow Cytometric Platform for the Precise Quantification of MicroRNA Based on Single Molecule Extension-Illuminated Microbeads (dFlowSeim). Chemical Communication, 2020, 56, 7179-7182.

五、 已申请专利

(1)一种微流控芯片器件、制备方法及微球载入方法, 2024-01-26, 中国, CN202410109276.7；

(2)一种微流控芯片及其制备方法和微流控-SERS平台, 2024-01-30, 中国, CN202410132566.3；

(3)基于流式细胞仪单荧光颗粒计数的核酸标志物数字式绝对定量分析方法, 2019-12-25, 中国, CN201911351145.5；