李娟娟

一、个人简介

李娟娟，南开大学博士（2019-2022），南开大学博士后(2022-2023），于2023年11月入职河北大学化学与材料科学学院。现为河北大学校聘副教授，硕士研究生导师。主要从事糖基修饰超分子功能材料的研究。迄今为止，在Nat. Commun., ACS Nano, J. Control. Release, Mater. Horiz., 等知名学术期刊上共发表SCI论文20余篇。其中，第一作者论文7篇。主持河北大学高层次人才科研启动项目1项。

联系方式：E-mail: juanjuanli0313@163.com

二、研究方向

1. 糖基修饰超分子功能材料的设计合成

2. 药物递送

三、代表性研究成果：

1. Meng-Meng Chen^#, Xingchen Tang^#, Juan-Juan Li^#, Fang-Yuan Chen, Ze-Tao Jiang, Rong Fu, Hua-Bin Li, Xin-Yue Hu, Wen-Chao Geng*, Dong-Sheng Guo*, Active targeting tumor therapy using host-guest drug delivery system based on biotin functionalized azocalix[4]arene, J. Control. Release, 2024, accepted.

2. Shihui Li^#, Juan-Juan Li^#, Ying-Ying Zhao, Meng-Meng Chen, Shan-Shan Su, Shun-Yu Yao, Ze-Han Wang, Xin-Yue Hu, Wen-Chao Geng, Wei Wang*, Ke-Rang Wang* and Dong-Sheng Guo*. Supramolecular integration of multifunctional nanomaterial by mannose-decorated azocalixarene with Ginsenoside Rb1 for synergistic therapy of rheumatoid arthritis. ACS Nano, 2023, 17, 25468-25482.

3. Jianshuang Guo^#, Juan-Juan Li^#, Ze-Han Wang, Yang Liu, Yu-Xin Yue, Hua-Bin Li, Xiu-He Zhao, Yuan-Jun Sun, Ya-Hui Ding, Dong-Sheng Guo*, Liang Wang*, Yue Chen. Dual hypoxia-responsive supramolecular complex for cancer target therapy. Nat. Commun., 2023. 14, 5634.

4. Juan-Juan Li^#, Rui-Xue Rong^#, Yan Yang, Zong-Ying Hu, Bing Hu, Ying-Ying Zhao, Hua-Bin Li, Xin-Yue Hu*, Ke-Rang Wang*, Dong-Sheng Guo*. Triple targeting host-guest drug delivery system based on lactose-modified azocalix[4]arene for tumor ablation. Mater. Horiz., 2023, 10, 1689-1696.

5. Juan-Juan Li^#, Yuqing Hu^#, Bing Hu, Wenbo Wang, Haiqi Xu, Xin-Yue Hu, Fei Ding, Hua-Bin Li, Ke-Rang Wang*, Xinge Zhang*, Dong-Sheng Guo*. Lactose azocalixarene drug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosa infected diabetic ulcer. Nat. Commun., 2022, 13, 6279.

6. Tian-Xing Zhang^#, Juan-Juan Li^#, Hua-Bin Li and Dong-Sheng Guo*. Deep cavitand calixarene–solubilized fullerene as a potential photodynamic agent. Front. Chem., 2021, 9, 710808.

7. Juan-Juan Li, Ke-Rang Wang*, Ren-Feng Li, Jian-Xing Yang, Min Li, Hong-Xin Zhang, Zhi-Ran Cao and Xiao-Liu Li*. Synthesis, self-assembly behaviours and multivalent glycosidase inhibition effects of a deoxynojirimycin modified perylene bisimide derivative. J. Mater. Chem. B, 2019, 7, 1270.

四、科研项目

1. 河北大学高层次人才科研启动项目（2023.12-2027.12，主持人）